Tag Archives: Alzheimer’s

On nodding syndrome

A DISEASE mystery with no shortage of leads now has an intriguing new one. Since the 1960s, thousands of children in poor, war-torn regions of East Africa have developed epilepsy-like seizures in which their heads bob to their chest; over time, the seizures worsen, cognitive problems develop, and the victims ultimately die. Researchers have proposed causes for nodding syndrome that include malnutrition, parasites, and viruses, but have not proved a clear link to any of them. Now, the first published examination of the brains of children who died after developing the condition suggests it has a key similarity to certain brain diseases of old age, such as Alzheimer’s and Parkinson’s: It leaves victims’ brains riddled with fibrous tangles containing a protein called tau…

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This article first appeared in Science on 21 December 2018. To continue reading, click here (paywall).

The forgetting gene

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ONE day in 1991, neurologist Warren Strittmatter asked his boss to look at some bewildering data. Strittmatter was studying amyloid-β, the main component of the molecular clumps found in the brains of people with Alzheimer’s disease. He was hunting for amyloid-binding proteins in the fluid that buffers the brain and spinal cord, and had fished out one called apolipoprotein E (ApoE), which had no obvious connection with the disease…

This article was inspired by an Ernst Strüngmann forum on brain diseases in March 2014 and first published in Nature on 6 June 2014. To continue reading, click here.

The following is an excerpt from Louis Theroux’s 2012 BBC documentary Extreme Love: Dementia. Don’t miss the bit where Nancy comes into the room and says, “I want you.”